Preheat the oven to 350°F. In a large pan on medium-heat, add the 3/4 pound lean ground beef, half of the diced onion, 1 teaspoon fine sea salt, 1/2 teaspoon ground black pepper, 1/2 teaspoon garlic powder, and 1/2 teaspoon onion powder. Cook until the beef is no longer pink and cooked through, about 5-7 minutes.
Carefully cut the 12 Slider buns or Hawaiian rolls in half lengthwise with a serrated or sharp knife. Set aside.
In a small bowl, combine the 1/4 cup mayonnaise, 2 tablespoons relish, 2 tablespoons yellow mustard, 2 tablespoons ketchup, 1 teaspoon paprika, 1/2 teaspoon onion powder and 1/2 teaspoon garlic powder and mix. Spread half of the sauce on the bottom layer of the rolls.
Top with the cooked beef, 6 slices American or sharp cheddar cheese, 1/2 cup iceberg lettuce, and 1/4 cup pickles. Drizzle the remaining sauce on top and place the top half of bread rolls on the sliders.
Brush the melted 2 tablespoons salted butter on top of the sliders and then top with sesame seeds (optional).
Bake the sliders for 10-15 minutes or until the cheese has melted. Let sliders cool for a few minutes and then cut into 12 sliders.
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